Liver hepatocellular carcinoma (LIHC) represents the predominant subtype of liver cancer, which is characterized by high rates of occurrence and fatality, and imposes a significant burden on health systems worldwide.1 Mitochondria have garnered significant attention within the context of cancer research as key organelles. Mitochondrial dynamics constitute a part of the mitochondrial quality control system, encompassing mitochondrial fission, fusion, mitophagy, and transport, which are critical for maintaining mitochondrial function and cellular homeostasis.2,3 In cancer, mitochondrial dynamics play a significant role in tumor development, progression, and response to therapy. The balance between fission and fusion is tightly regulated, and dysregulation of these processes is often observed in cancer cells, contributing to their altered metabolism, resistance to apoptosis, and increased invasiveness.4 There has been a growing emphasis on mitochondrial dynamics-related genes (MDRGs) in oncology.5 However, comprehensive studies exploring the roles of MDRGs in LIHC are relatively rare.