基因与疾病（英文）

Genes & Diseases 入选2024年度《科技期刊世界影响力指数（WJCI）报告》和“中国最具国际影响力学术期刊”

论文投稿

科普投稿

期刊视频

Genes&Diseases视频简介

Genes & Diseases 创刊十周年特辑——主编访谈（二）

Genes & Diseases 创刊十周年特辑 ——主编访谈

Cerebral furin deficiency causes hydrocephalus in mice

人物专访

【人物专访】河南大学郭向前教授：解密肿瘤生物标志物，助力肿瘤早筛早诊

郭向前，教授、博士、黄河学者、杰出人才特区特聘教授、博士生导师、河南大学基础医学院副院长、基础医学院特聘教授、医学生物信息学研究所所长、河南省肿瘤分子诊断与精准治疗工程技术研究中心副主任。荣获中国药学发展奖临床医药研究奖杰出青年学者奖，河南省学术技术带头人，河南省高层次人才，河南省高校科技创新人才（考核优秀），中原千人计划青年拔尖人才，河南省教育厅学术技术带头人，河南省高等学校青年骨干教师，开封市优秀教师等。已发表 SCI 论文97 篇（包括三篇高被引论文，一篇热点论文，一篇亮点文章和两篇封面文章），论文期刊影响因子之和达到735.551，单篇平均影响因子 7.58，论文被引用 3800 多次，个人 H index 为 24。获批软件著作权 27 件、专利 1 件。近年来，主要从事肿瘤分子分型、基因标志物及靶标筛选、医学生物信息学等研究。目前是 Frontiers in Genetics 副主编及其他数个学术刊物的编委，同时还担任数十个杂志的审稿人。

【人物专访】重庆医科大学党永军教授：逐梦药学，功不唐捐

党永军，重庆医科大学特聘教授，生命科学研究院新靶标与化学干预研究中心主任，博士生导师。重庆英才·创新创业领军人才，巴渝学者计划讲座教授，重庆市高校创新研究群体负责人，上海市人才发展基金获得者。复旦大学遗传所博士，美国约翰霍普金斯大学医学院博士后。中国药理学会海洋药物药理专业委员会副主任委员，全国卫生产业企业管理协会医学遗传专委会常务委员，上海药理学会常务理事。

作者分享

长链非编码RNA的甲基化修饰在胰腺癌进展中的作用

2024年6月19日，“Genes & Diseases 创刊十周年系列活动之学术交流会”第1期邀请了浙江大学医学院附属儿童医院彭琬昕特聘研究员作题为“长链非编码RNA的甲基化修饰在胰腺癌进展中的作用”的精彩报告，4000+人次参与此次线上直播。

黄腾博士:核心启动子变异在癌症中的病因学作用

Genes & Diseases创刊十周年系列活动之学术交流会作者分享第2期核心启动子变异在癌症中的病因学作用

前沿讨论

SPP1+ macrophages in colorectal cancer: Markers of malignancy and promising therapeutic targets

SPP1+ macrophages have been identified as key players in the colorectal cancer (CRC) tumor microenvironment, but their function remains unclear. This study integrated single-cell and spatial transcriptomics with bulk sequencing to investigate the roles and mechanisms of SPP1+ macrophages in CRC. Our findings revealed a pronounced elevation of SPP1+ macrophages in CRC, especially within tumor territories. These macrophages served as markers for CRC initiation, progression, metastasis, and potential prognosis. Furthermore, they showed heightened transcriptional activity in genes linked to angiogenesis, epithelial–mesenchymal transition, glycolysis, hypoxia, and immunosuppression. SPP1 protein amplified CRC cell migration and invasion, potentially mediating cellular crosstalk via the SPP1-CD44, SPP1-PTGER4, and SPP1-a4b1 complex axes. Patients with a high proportion of SPP1+ macrophages could benefit more from immune checkpoint blockade therapy. Interestingly, CSF1R expression was significantly enriched in C1QC+ macrophages versus SPP1+ macrophages, possibly explaining limited anti-CSF1R monotherapy effects. In conclusion, we propose an SPP1+ macrophage model in CRC, highlighting such macrophages as a promising therapeutic target due to their malignancy markers.

新闻动态

最新CiteScore™ 2023发布：Genes & Diseases 7.3

CiteScore™官方发布：2023年度Genes & Diseases CiteScore分值为7.3，SJR 1.446，SNIP 1.228。

重磅｜Genes & Diseases 最新影响因子6.9

2024年6月20日中午，据科睿唯安（Clarivate Analytics）发布了2023年度最新SCI《期刊引证报告》（Journal Citation Reports，简称JCR）显示，由重庆医科大学主办的 Genes & Diseases 《基因与疾病(英文)》最新影响因子为6.9！在Biochemistry & Molecular Biology 和 Genetics & Heredity 两个学科均位于Q1区！Biochemistry & Molecular Biology 36/313；Genetics & Herediy 16/191。

秒读论文

Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis

Progranulin (PGRN) is a multifunctional growth factor involved in many physiological processes and disease states. The apparent protective role of PGRN and the importance of chondrocyte autophagic function in the progression of osteoarthritis (OA) led us to investigate the role of PGRN in the regulation of chondrocyte autophagy. PGRN knockout chondrocytes exhibited a deficient autophagic response with limited induction following rapamycin, serum starvation, and IL-1b-induced autophagy. PGRN-mediated anabolism and suppression of IL-1b-induced catabolism were largely abrogated in the presence of the BafA1 autophagy inhibitor. Mechanistically, during the process of OA, PGRN and the ATG5eATG12 conjugate form a protein complex; PGRN regulates autophagy in chondrocytes and OA through, at least partially, the interactions between PGRN and the ATG5eATG12 conjugate. Furthermore, the ATG5eATG12 conjugate is critical for cell proliferation and apoptosis. Knockdown or knockout of ATG5 reduces the expression of ATG5eATG12 conjugate and inhibits the chondroprotective effect of PGRN on anabolism and catabolism. Overexpression of PGRN partially reversed this effect. In brief, the PGRN-mediated regulation of chondrocyte autophagy plays a key role in the chondroprotective role of PGRN in OA. Such studies provide new insights into the pathogenesis of OA and PGRN-associated autophagy in chondrocyte homeostasis.

Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis

Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as a new mode of intercellular crosstalk and are responsible for many of the therapeutic effects of MSCs. To promote the application of MSC-EVs, recent studies have focused on the manipulation of MSCs to improve the production of EVs and EV-mediated activities. The current paper details an optimization method using non-invasive low-intensity pulsed ultrasound (LIPUS) as the stimulation for improving oral MSC-EV production and effectiveness. Stem cells from apical papilla (SCAP), a type of oral mesenchymal stem cell, displayed intensity-dependent pro-osteogenic and anti-inflammatory responses to LIPUS without significant cytotoxicity or apoptosis. The stimuli increased the secretion of EVs by promoting the expression of neutral sphingomyelinases in SCAP. In addition, EVs from LIPUS-induced SCAP exhibited stronger efficacy in promoting the osteogenic differentiation and anti-inflammation of periodontal ligament cells in vitro and alleviating oral inflammatory bone loss in vivo.In addition, LIPUS stimulation affected the physical characteristics and miRNA cargo of SCAP-EVs. Further investigations indicated that miR-935 is an important mediator of the pro-osteogenic and anti-inflammatory capabilities of LIPUS-induced SCAP-EVs. Taken together, these findings demonstrate that LIPUS is a simple and effective physical method to optimize SCAP-EV production and efficacy.

科普播客

宫颈炎——育龄女性看过来

宫颈炎是育龄女性常见的一种妇科疾病，给她们身体和心理带来不小的伤害。面对近年来宫颈炎的发病率不断上升的现状，在日常生活中养成良好的生活习惯，做好护理，是有效降低患上宫颈炎几率的最便捷途径。

尿路感染的痛，希望你一辈子别懂

尿频、尿急、尿痛、尿不尽

友好期刊

友情链接