基因与疾病（英文）

论文投稿

科普投稿

期刊视频

Genes&Diseases视频简介

十周年纪念视频

Genes & Diseases 创刊十周年特辑——主编访谈（二）

Genes & Diseases 创刊十周年特辑 ——主编访谈

人物专访

【人物专访】重庆医科大学党永军教授：逐梦药学，功不唐捐

党永军，重庆医科大学特聘教授，生命科学研究院新靶标与化学干预研究中心主任，博士生导师。重庆英才·创新创业领军人才，巴渝学者计划讲座教授，重庆市高校创新研究群体负责人，上海市人才发展基金获得者。复旦大学遗传所博士，美国约翰霍普金斯大学医学院博士后。中国药理学会海洋药物药理专业委员会副主任委员，全国卫生产业企业管理协会医学遗传专委会常务委员，上海药理学会常务理事。

【人物专访】重庆大学罗阳教授：科学服务人民

罗阳，重庆大学医学院智慧检验与分子医学中心主任，教授，博士生导师，重庆市学术技术带头人，国家科技部运动损伤修复与重建创新团队核心骨干，国家杰出青年科学基金项目及科技部重点研发课题负责人。教授从生活细微处着手解决老百姓关心的问题，带领团队进行多学科联合解决科研难题，实现多项技术突破。在科研之余，他还致力于医学科普工作，让科学服务于人民。

作者分享

长链非编码RNA的甲基化修饰在胰腺癌进展中的作用

2024年6月19日，“Genes & Diseases 创刊十周年系列活动之学术交流会”第1期邀请了浙江大学医学院附属儿童医院彭琬昕特聘研究员作题为“长链非编码RNA的甲基化修饰在胰腺癌进展中的作用”的精彩报告，4000+人次参与此次线上直播。

黄腾博士:核心启动子变异在癌症中的病因学作用

Genes & Diseases创刊十周年系列活动之学术交流会作者分享第2期核心启动子变异在癌症中的病因学作用

前沿讨论

SPP1+ macrophages in colorectal cancer: Markers of malignancy and promising therapeutic targets

SPP1+ macrophages have been identified as key players in the colorectal cancer (CRC) tumor microenvironment, but their function remains unclear. This study integrated single-cell and spatial transcriptomics with bulk sequencing to investigate the roles and mechanisms of SPP1+ macrophages in CRC. Our findings revealed a pronounced elevation of SPP1+ macrophages in CRC, especially within tumor territories. These macrophages served as markers for CRC initiation, progression, metastasis, and potential prognosis. Furthermore, they showed heightened transcriptional activity in genes linked to angiogenesis, epithelial–mesenchymal transition, glycolysis, hypoxia, and immunosuppression. SPP1 protein amplified CRC cell migration and invasion, potentially mediating cellular crosstalk via the SPP1-CD44, SPP1-PTGER4, and SPP1-a4b1 complex axes. Patients with a high proportion of SPP1+ macrophages could benefit more from immune checkpoint blockade therapy. Interestingly, CSF1R expression was significantly enriched in C1QC+ macrophages versus SPP1+ macrophages, possibly explaining limited anti-CSF1R monotherapy effects. In conclusion, we propose an SPP1+ macrophage model in CRC, highlighting such macrophages as a promising therapeutic target due to their malignancy markers.

新闻动态

最新CiteScore™ 2023发布：Genes & Diseases 7.3

CiteScore™官方发布：2023年度Genes & Diseases CiteScore分值为7.3，SJR 1.446，SNIP 1.228。

重磅｜Genes & Diseases 最新影响因子6.9

2024年6月20日中午，据科睿唯安（Clarivate Analytics）发布了2023年度最新SCI《期刊引证报告》（Journal Citation Reports，简称JCR）显示，由重庆医科大学主办的 Genes & Diseases 《基因与疾病(英文)》最新影响因子为6.9！在Biochemistry & Molecular Biology 和 Genetics & Heredity 两个学科均位于Q1区！Biochemistry & Molecular Biology 36/313；Genetics & Herediy 16/191。

秒读论文

Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis

Progranulin (PGRN) is a multifunctional growth factor involved in many physiological processes and disease states. The apparent protective role of PGRN and the importance of chondrocyte autophagic function in the progression of osteoarthritis (OA) led us to investigate the role of PGRN in the regulation of chondrocyte autophagy. PGRN knockout chondrocytes exhibited a deficient autophagic response with limited induction following rapamycin, serum starvation, and IL-1b-induced autophagy. PGRN-mediated anabolism and suppression of IL-1b-induced catabolism were largely abrogated in the presence of the BafA1 autophagy inhibitor. Mechanistically, during the process of OA, PGRN and the ATG5eATG12 conjugate form a protein complex; PGRN regulates autophagy in chondrocytes and OA through, at least partially, the interactions between PGRN and the ATG5eATG12 conjugate. Furthermore, the ATG5eATG12 conjugate is critical for cell proliferation and apoptosis. Knockdown or knockout of ATG5 reduces the expression of ATG5eATG12 conjugate and inhibits the chondroprotective effect of PGRN on anabolism and catabolism. Overexpression of PGRN partially reversed this effect. In brief, the PGRN-mediated regulation of chondrocyte autophagy plays a key role in the chondroprotective role of PGRN in OA. Such studies provide new insights into the pathogenesis of OA and PGRN-associated autophagy in chondrocyte homeostasis.

Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis

Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as a new mode of intercellular crosstalk and are responsible for many of the therapeutic effects of MSCs. To promote the application of MSC-EVs, recent studies have focused on the manipulation of MSCs to improve the production of EVs and EV-mediated activities. The current paper details an optimization method using non-invasive low-intensity pulsed ultrasound (LIPUS) as the stimulation for improving oral MSC-EV production and effectiveness. Stem cells from apical papilla (SCAP), a type of oral mesenchymal stem cell, displayed intensity-dependent pro-osteogenic and anti-inflammatory responses to LIPUS without significant cytotoxicity or apoptosis. The stimuli increased the secretion of EVs by promoting the expression of neutral sphingomyelinases in SCAP. In addition, EVs from LIPUS-induced SCAP exhibited stronger efficacy in promoting the osteogenic differentiation and anti-inflammation of periodontal ligament cells in vitro and alleviating oral inflammatory bone loss in vivo.In addition, LIPUS stimulation affected the physical characteristics and miRNA cargo of SCAP-EVs. Further investigations indicated that miR-935 is an important mediator of the pro-osteogenic and anti-inflammatory capabilities of LIPUS-induced SCAP-EVs. Taken together, these findings demonstrate that LIPUS is a simple and effective physical method to optimize SCAP-EV production and efficacy.

科普播客

宫颈炎——育龄女性看过来

宫颈炎是育龄女性常见的一种妇科疾病，给她们身体和心理带来不小的伤害。面对近年来宫颈炎的发病率不断上升的现状，在日常生活中养成良好的生活习惯，做好护理，是有效降低患上宫颈炎几率的最便捷途径。

尿路感染的痛，希望你一辈子别懂

尿频、尿急、尿痛、尿不尽

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