Lysine-specific demethylase 1 (LSD1), as a histone lysine demethylase, demethylates monomethyl and dimethyl of histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9). Studies have reported that high LSD1 expression promotes cell proliferation, migration, and invasion by regulating chromatin morphology and gene expression, and is closely related to the development of non-small cell lung cancer (NSCLC). However, the underlying mechanism of LSD1 on cell proliferation and migration remains unclear.