Genes&Diseases

语种：英文出版周期：双月刊

E-ISSN：2352-3042P-ISSN：2352-4820

主管单位：重庆市教育委员会主办单位：重庆医科大学

Genes and Diseases是本由重庆医科大学于2014年创办的双月刊，也是国内第一本分子医学与转化医学相结合的全英文综合期刊，并入选“中国科技期刊卓越行动计划”高起点新刊项目。

过刊浏览

LncMIR31HG acts as a host gene for miR-31, also known as LncHIFCAR (long non-coding HIF-1 co-activating RNA), whose deregulation has been reported to promote the development of various human cancers, including lung cancer, colorectal cancer, etc. However, the biological functions and molecular mechanisms of MIR31HG in gastric cancer are unclear. The lncRNA MIR31HG was identified as a possible therapeutic target for gastric cancer throughout our work. In summary, we found that MIR31HG plays an oncogene role in gastric cancer; the deletion of MIR31HG significantly reduced gastric cancer cell proliferation, metastasis, and sphereforming ability; and the overexpression of MIR31HG promoted these capacities. FH535, a small molecule targeting β-catenin, was utilized to confirm that MIR31HG, which directs the malignant progression of gastric cancer, is β-catenin dependent. We revealed that MIR31HG positively regulated β-catenin stability by reducing β-catenin ubiquitination and increasing β-catenin steady-state expression. Furthermore, this is the first time that MIR31HG has been shown to interact with the E3 ligase c-CBL (dendritic cell (DC) -specific defect of casitas B-lineage lymphoma), and that c-CBL is reported to be involved in regulating β-catenin ubiquitination in cancer cells. MIR31HG interacted with c-CBL and caused its instability to protect β-catenin stability. Thus, our study provided insights into the applicability of using the MIR31HG-c-CBL-β-catenin axis as a potential therapeutic target in gastric cancer.

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