Among the most common malignancies, colorectal cancer (CRC) has a high incidence and mortality rate.1 Matrix metalloproteinase 2 (MMP2) plays an important role in the migration and invasion of malignant tumor cells.2 Although many trans-activating factors of MMP2 have been identified, relatively little is known about MMP2 transcriptional inhibition. In this study, we found that zinc finger transcription factor ZNF24 (zinc finger protein 24) may be a novel transcriptional repressor of MMP2 expression.