Oral cancer, primarily oral squamous cell carcinoma (OSCC), is one of the most common cancer types worldwide. The incidence of OSCC continues to rise, with approximately 377,713 new cases and 177,757 deaths reported worldwide by 2020.1 Despite advancements in diagnosis and treatment, the 5-year survival rate for OSCC patients has remained at 60%–67% over the last two decades (SEER database: https://seer.cancer.gov/). This consistent rise in morbidity and lack of survival improvement have made OSCC a public concern.