Bone mesenchymal stem cells (BMSCs) are stem cells located in the bone marrow matrix that have a variety of differentiation potentials and biological functions. They play an important role in bone regenerative medicine. The senescence of BMSCs might cause accelerated degeneration of bone tissue. Autophagy is a process in which cellular homeostasis is maintained by autophagosomes and lysosomes. It could control the function and senescence of BMSCs during bone aging and might be a therapeutic target for treating diseases during aging.1 Ferroptosis is a regulated cell death process.2 The inhibition of ferroptosis in mesenchymal stem cells could reduce cell injury and might have great therapeutic value.3, 4, 5