Endometrial cancer (EC) is the second most prevalent female reproductive system tumor after cervical cancer and its incidence is rising globally. Recently, N6-methyladenosine (m⁶A) has emerged as an important regulator of a variety of physiological and pathological processes, especially in promoting EC progression. However, the potential roles of m⁶A modification in EC and its immune landscape remain unknown. Here, the correlation between m⁶A modification patterns and tumor microenvironment (TME) cell-infiltrating characteristics was comprehensively evaluated based on 21 m⁶A regulators of 1301 endometrial cancer samples. We identified four m6Aclasses characterized by distinct TME cell infiltration. We used principal component analysis algorithms to construct m6Ascore to quantify m⁶A modification patterns of endometrial cancer individuals. Our results showed that lower m6Ascore may be closely related to immune-inflamed phenotype and displayed immune-activated characteristics and better prognosis, while higher m6Ascore may be associated with immune-desert and immune-excluded phenotype and showed interstitial activation-related characteristics and poor prognosis. These new findings reveal that m⁶A modification played a nonnegligible role in the formation of TME diversity and complexity and support the possibility of targeting m⁶A modification patterns for rescuing EC, which were unreported in EC patients.