Immunogenic death is a form of programmed cell death that is common in the development and progression of cancer. However, its impact on tumor progression differs depending on the location of the tumor. Meanwhile, it also plays an important role in antitumor immunity because the process of immunogenic death can release substances that activate immunity. Therefore, in this study, the key mechanism of mediating immunogenic death in hepatocellular carcinoma (HCC) was found from the excavation of the immunogenic death characteristics of pan-cancer and the in-depth investigation of its effects on different tumor types