Circular RNAs (circRNAs) are endogenous RNAs formed by back-splicing1 and possess a more stable molecular structure.2 circRHOT1 promotes HCC progression by inducing nuclear receptor subfamily 2 group F member 6 (NR2F6) expression3 and m6A-mediated up-regulation of circMDK and circSTX6 facilitates tumorigenesis.4 Wang et al revealed that circTGFBR2 was a novel tumor promoter circRNA and promoted HCC progression.5 However, the role and molecular mechanism of circ-miR-524 in hepatocarcinogenesis have been poorly elucidated. In this study, we clearly demonstrate that circ-miR-524 accelerates the growth of liver cancer cells by altering transcriptome, proteome, and DNA damage repair. In particular, circ-miR-524 enhances the expression of K-RAS, which determines the carcinogenic function of miR-circ-524. These results provide a basis for research on liver cancer prevention, diagnosis, and treatment.