ADAM8 (ADAM metallopeptidase domain 8, aka MS2/CD156/CD156a) is a membrane-anchored proteinase. ADAM8 and its proteolytic product, fibronectin fragments, are elevated in degenerative human intervertebral discs (IVDs).1 Pathological fibronectin fragments can trigger further disc degeneration. ADAM8 proteolytic activities and fibronectin fragments may accelerate degenerative disc disease, a common clinical problem leading to tremendous socioeconomic burdens in the United States.