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Roles of Setbp1 in developmental hematopoiesis and acute myeloid leukemia

Rapid Communications

Roles of Setbp1 in developmental hematopoiesis and acute myeloid leukemia

Ao Fei
Chen Fan
Lv Minhong
Cao Yuming
Xu Jinfeng
Xu Jingbo
Leung Anskar Yu - Hung
Yuan Qiwen
Wang Li
He Bailiang
Genes & Diseases第11卷, 第6期纸质出版 2024-11-01在线发表 2023-12-13
3900

Gain-of-function somatic mutations of SET binding protein 1 (SETBP1) result in the accumulation of SETBP protein and are detected in 17% of secondary acute myeloid leukemia (AML) patients.1 In fact, high expression of SETBP1 also drives adverse outcomes in human AML. However, the roles of SETBP1 during developmental hematopoiesis and AML progression are still not fully understood.

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