Chronic myelogenous leukemia (CML) is a malignancy from bone marrow myeloid stem cells mainly driven by the fusion gene BCR-ABL. In addition to BCR-ABL, other genes including RNF6 are also dysregulated in CML cells. RNF6, a ubiquitin ligase of the RING family, promotes various cancer cell proliferation, chemoresistance, and tumor growth in vivo by targeting various proteins for ubiquitination and degradation, including SHP1, TLE3, FOXA1, and MAD1. However, its specific mechanism in CML is not known.