The m⁶A modification involves almost all aspects of RNA biology, including the alternative splicing of mRNA precursors, mRNA transport and stability, and miRNA processing and regulation of target genes. Alternative splicing controlling the information storage and RNA translation involves the regulation of various biological processes. Here, we integrated the genomic information of 161 esophageal cancer (EC) samples to comprehensively evaluate the m⁶A modification patterns and correlated the m⁶A modification pattern with the prognosis of EC patients, where two distinct m⁶A modification patterns were proposed. The combined effects of high m⁶Ascore and low TMB correlated with a better prognosis of EC patients. In addition, we found an inherent correlation between m⁶A modification and the occurrence of alternative splicing events in EC patients. Altogether, we established a scoring system to quantify the m⁶A modification pattern with RNA alternative splicing events in individual EC patients.