EBV-positive diffuse large B-cell lymphoma (DLBCL), which has a clonal EBV carrying proliferation of B-cells, defines a new DLBCL subtype and predicts a poor prognosis. Further studies are needed to explore the underlying mechanisms in EBV lymphomagenesis. EBV encoded microRNAs (miRNAs) have been proven to contribute to the pathogenesis and oncogenesis of EBV-associated malignancies. In this study, research has focused on the pathological roles of miRNAs in EBV-positive DLBCL progression and survival, which might provide ideas for therapeutic decision to improve the prognosis.