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Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway

Rapid Communications

Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway

Wang Hui
Li Zhonghao
Wang Qisheng
Lin Weixin
Zhou Ziting
Mu Xinru
Jiang Yongwei
Lu Shengfeng
Chen Shaodong
Lu Zhigang
Genes & Diseases第11卷, 第3期纸质出版 2024-05-01在线发表 2023-07-28
1200

Opioid abuse can suppress the lymphatic system function, and produce severe immunosuppression that poses a significant risk of opportunistic infections such as methicillin-resistant Staphylococcus aureus (MRSA) pneumonia.1,2 Gypenosides (Gps) are the most important immunomodulator components in the Chinese herbal medicine Gynostemma pentaphyllum.3 However, the immunomodulatory mechanism and effect of Gps on morphine-induced immunosuppression are still unknown. We aimed to investigate the pharmacological effects of Gps in morphine-induced immunosuppressive mice and the underlying mechanism involved.

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