Uncoupling protein 1 (UCP1, also known as thermogenin or SLC25A7) plays an important role in the uncoupling of oxidative phosphorylation and adaptive non-shivering thermogenesis (NST). The genomic location for UCP1 is chromosome 4 q31.1:140,555,770–140,568,961 (GRCh38/hg38) and its size is 13,192 bases split into 6 exons. In dbSNP, 3650 short genetic variations of human UCP1 are documented. In this study, UCP1 serves as an example to construct polymorphism-trait networks and enable a functional classification.