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Adeno-associated virus-mediated intraprostatic suppression of MIR375 inhibits tumor progression in the TRAMP mouse model of prostate cancer

Rapid Communications

Adeno-associated virus-mediated intraprostatic suppression of MIR375 inhibits tumor progression in the TRAMP mouse model of prostate cancer

Yi Xianyanling
Li Jin
Han Zeyu
Zhang Tianyi
Liao Dazhou
You Jia
Ai Jianzhong
Genes & Diseases第11卷, 第6期纸质出版 2024-11-01在线发表 2023-11-23
3500

The treatment of prostate cancer (PCa) needs to be improved.1 Micro-RNAs (miRNAs) are a subtype of non-coding, single-stranded RNAs that influence cellular survival and death by modulating mRNAs. Among these miRNAs, MIR375 has a critical role in the regulation of tumorigenesis2 and holds promise as a novel therapeutic target for future PCa treatment. Recombinant adeno-associated virus (rAAV) exhibits non-pathogenicity, low-grade inflammation, and robust and long-lasting expressions of target genes. We have previously described the rAAV9 as a valid vector to transfer target miRNAs and genes,3 so rAAV9 could be used as a vector to deliver MIR375 into the mouse prostate and PCa cells.

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