Obesity is caused by an excessive accumulation of fat, which poses a risk to human health. In China, the prevalence rates of overweight and obesity in adults were estimated to be 30.1% and 11.9%, respectively, ranking the first in the world. Obesity is a major risk factor for hypertension. However, most of the overweight adults maintain normal blood pressure (BP), and only ~43.6% of obese people developed hypertension. The mechanism and key link for promoting obesity to hypertension are still unclear. Genome-wide association studies (GWAS) attempt to discover genetic variations that associate with obesity and hypertension. Although these studies suggest a close relationship between obesity and hypertension, only 10%-20% of the increase in BP can be explained by increased body mass index (BMI). In this study, we observed that several genes were associated with both hypertension and obesity, which gave us an opportunity to find and identify the common genetic background of hypertension and obesity, or obesity-related hypertension.