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3′-UTR of the SARS-CoV-2 genome as a possible source of piRNAs

RAPID COMMUNICATION

3′-UTR of the SARS-CoV-2 genome as a possible source of piRNAs

María Teresa Hernández-Huerta
Laura Pérez-Campos Mayoral
Carlos Alberto Matias-Cervantes
Carlos Romero Díaz
Eli Cruz Parada
Pérez-Campos Mayoral Eduardo
Rafael Baltiérrez-Hoyos
Margarito Martínez Cruz
Gabriel Mayoral Andrade
Eduardo Pérez-Campos
Genes & Diseases第10卷, 第3期pp.668-670纸质出版 2023-05-01在线发表 2022-06-08
114500

SARS-CoV-2 is the causal agent of the COVID-19 pandemic. This is a single-stranded RNA beta-coronavirus that is comprised of a 5′ and 3′-untranslated region (UTR) in its non-coding RNA (ncRNA) region. The P-element-induced wimpy testis (PIWI) -interacting RNAs (piRNAs) are ncRNA sequences that bind to transposons and interfere with the translation of new genes. Here, we search for short sequences in the non-coding regions, corresponding to 28 nucleotides (nt). These start from a uracil and have a conserved region of at least 10 nt of homology with the previously reported piRNAs. The aim of this work was to identify piRNA-like sequences in the 3′-UTR of SARS-CoV-2 from the reported Wuhan Patient's genome sequence (GenBank: MN908947.3).

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