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The functions of N6-methyladenosine modification in lncRNAs

The functions of N6-methyladenosine modification in lncRNAs

Rong-Zhang He
Jing Jiang
Di-Xian Luo
Genes & Diseases第7卷, 第4期pp.598-605纸质出版 2020-12-01在线发表 2020-03-19
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Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most abundant modification of RNA. Extensive studies of m6A modification of mRNAs have been carried out, while little is known about m6A modification of long non-coding RNAs (lncRNAs). Recently, several studies reported m6A modification of lncRNAs. In this review, we focus on these m6A-modified lncRNAs and discuss possible functions of m6A modification.

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