Lgr6 has attracted significant attention in biomedical research in recent years. As a member of the G protein-coupled receptor family, Lgr6 plays a crucial role in the occurrence and development of various diseases, including diabetic cardiomyopathy, bone regeneration defects, and skin injury repair, where it is vitally involved in cellular signal transduction. This study endeavors to investigate the distribution and functions of Lgr6+ cells across organisms, particularly during homeostasis and damage scenarios. Lgr6+ expression occurs across skin, mammary glands, kidneys, and intestines, crucial for development and tissue repair. Abnormal expression of Lgr6 is also observed in the onset and progression of major systemic diseases, especially in tumors. Thus, Lgr6 has been identified as a promising therapeutic target for cancer and other diseases, influencing their onset, progression, and treatment.