Early studies utilized microarrays to identify liver-enriched genes, and the roles of some of these genes in liver development in mice and zebrafish were confirmed.1,2 However, many genes involved in liver growth regulation remained unidentified through this approach. Recently, bulk RNA sequencing or single-cell RNA sequencing has been used to study liver differentiation,3 but no study has screened genes highly expressed in hepatocytes during liver growth. Since rapid hepatocyte proliferation is a common characteristic of liver growth in early liver development and hepatocellular carcinoma (HCC) progression, identifying the genes being involved in regulating liver growth and clarifying how it works would benefit studying HCC progress.