CARM1 (coactivator-associated arginine methyltransferase 1) is a type I protein arginine methyltransferase and a binding protein of the p160 coactivator family.1 Moreover, the research shows that the absence of CARM1 leads to impaired adipocyte differentiation2 and disrupts normal differentiation of embryonic T cells.3 In addition, other studies have confirmed that CARM1 induces the expression of pluripotent genes Oct4 and Sox2 through methylation modification of histone H3, thereby damaging embryonic stem cell differentiation.4 Furthermore, it can be indicated that CARM1 plays an important role in different types of tumors through various pathways.5 Notably, it is well known that ARAF (v-raf murine sarcoma 3611 viral oncogene homolog) regulates cell proliferation and differentiation abilities. In this study, it is revealed that CARM1 affects the epigenetic modification, transcriptome, and proteome to regulate the expression of related genes in liver cancer, thus regulating cell proliferation, cell metabolism, cell cycle, and other biological processes in liver cancer cells. These results provide a valuable theoretical basis for further exploring the cellular and molecular mechanisms of CARM1 promoting the occurrence and development of liver cancer at the cellular and molecular levels.