The coronavirus disease 2019 (COVID-19) is still a global threat today. SARS-CoV-2 is the etiologic agent of COVID-19, the culprit behind the current pandemic. Its life cycle is dependent on hijacking host-cell biological processes to facilitate entry, replication, assembly, and budding. The recognition that a suite of mammalian host proteins is required for SARS-CoV-2 infection and replication presents additional targeting strategies that may be less prone to deflections by the quickly mutating viral genome. In this study, we conducted an integrative network analysis to identify pivotal host genes and pathways for SARS-CoV-2 infection.