全部
logo

Novel perspectives on leptin in osteoarthritis: Focus on aging

Review Articles

Novel perspectives on leptin in osteoarthritis: Focus on aging

Liu Zimo
Xie Wenqing
Li Hengzhen
Liu Xu
Lu Yao
Lu Bangbao
Deng Zhenhan
Li Yusheng
Genes & Diseases第11卷, 第6期纸质出版 2024-11-01在线发表 2023-11-04
4000

Osteoarthritis (OA) is a common chronic joint disease characterized by articular cartilage degeneration, subchondral sclerosis, synovitis, and osteophyte formation. OA is associated with disability and impaired quality of life, particularly among the elderly. Leptin, a 16-kD non-glycosylated protein encoded by the obese gene, is produced on a systemic and local basis in adipose tissue and the infrapatellar fat pad located in the knee. The metabolic mechanisms employed by leptin in OA development have been widely studied, with attention being paid to aging as a corroborative risk factor for OA. Hence, in this review, we have attempted to establish a potential link between leptin and OA, by focusing on aging-associated mechanisms and proposing leptin as a potential diagnostic and therapeutic target in aging-related mechanisms of OA that may provide fruitful guidance and emphasis for future research.

pic
AgingArticular chondrocytesCellular senescenceDegenerationLeptinOsteoarthritis