Triple-negative breast cancer (TNBC) has a poor prognosis because of its aggressive characteristics and lack of targeted therapies. Recently, it has been reported that TNBC is sensitive to ferroptosis, an iron-dependent type of programmed cell death, making it a potential target for the treatment of TNBC. Breast cancer stem cells (BCSCs), a small population of cancer cells that possess the infinite proliferative potential and tumor-initiating properties, play important roles in drug resistance. The responses of BCSCs to ferroptosis-inducing agents are controversial and remain elusive.