Recently, Niculescu published an interesting paper concerning "deep homologies" between the formation of cancer stem cells by polyploidization and reproductive polyploidization of entamoeba. The life cycle of both systems shares the same genetic machinery inherited from the Last Eukaryote Common Ancestor (LECA). This theory claims that cancer is nothing more than the expression of a pre-existing life cycle that was reactivated in "sick and weakened metazoan cell that cannot continue its multicellular life and finds itself in the same dead-end situation". Proposed amoeba/cancer homologies actually comply with the theories claiming that cancer represents inverse recapitulation of metazoan differentiated cell evolution to the pro-metazoan stage. However, the real polyploidy formation, based on endoduplication, is not specific to cancer. There is, for example, polyploidization of normal hepatocytes and fibroblasts, especially in tissue regeneration. Endorduplication itself is a purely physiologic phenomenon during thrombopoiesis. In addition, this is not the only feature of the ancient single-cell eukaryote life cycle but is common to cancer and normal behavior of the primitive cell.