We read with great interest the manuscript "LPCAT1 functions as a novel prognostic molecular marker in hepatocellular carcinoma" by Zhang et al in a recent issue of Genes& Diseases. The authors conducted bioinformatics analyses using high throughput RNA sequencing data from TCGA to demonstrate that LPCAT1 is a novel and effective prognostic marker for hepatocellular carcinoma. We appreciate the contributions of the authors on the subject, nonetheless, we have some concerns that should be clarified in the following issues.