Renal cell carcinoma (RCC) is the third most common urological malignancy. Due to its high metastatic potential, approximately 20% of patients present with metastases at diagnosis. Autophagy, a form of programmed cell death (PCD) characterized by autophagosome formation and lysosome-mediated degradation, plays a crucial role in tumor biology. Given that membrane dynamics are essential throughout the autophagic process, RAB proteins, which are key regulators of membrane trafficking, have garnered increasing attention. Among them, RAB24 stands out as an atypical member due to its roles in basal autophagy and endosomal degradation. However, its function in clear cell RCC (ccRCC) remains largely unexplored, prompting us to investigate this research gap.